The MAHSC-CTU is a unit of over 50 highly experienced professionals with teams that specialise in trials and governance, quality and research grant support, data
management and systems, and biostatistics.
Our leadership consists of:
Kevin O’Brien was appointed Professor of Orthodontics in the Division of Dentistry at the University of Manchester in 1996. He has previously held posts in the USA and was Dean of Manchester Dental School from 2004-2007 and Associate Dean of the Faculty of Medical and Human Sciences from 2007-2010. He was Chair of the General Dental Council from 2011-2013 and appointed MAHSC-CTU Director in June 2016.
His main research interests are clinical trials of the care of children with severe dentofacial problems. He has published over 90 scientific papers, mostly in the American Journal of Orthodontics. Committed to teaching and research, he has obtained €7m external research funding. He has given the Northcroft Memorial and Ballard Lectures for the British Orthodontic Society and has been awarded the Turpin, Dewel and Jarabak awards by the American Association of Orthodontists. He currently writes an orthodontic blog (www.kevinobrienorthoblog.com).
For further details of Kevin’s research and publications, see his research profile at the University of Manchester.
MAHSC-CTU Deputy Director (Methodology)
Richard is Professor of Medical Statistics in the Centre for Biostatistics at the University of Manchester.
Richard’s research is focussed on answering four key questions: Are treatments effective? How do they work? Which groups are they most effective for? What factors make them work more effectively? This encompasses the development of statistical methods for causal inference, and efficacy and mechanisms evaluation. Current applications of these methods include trials of complex interventions in mental health and trial designs and associated analysis methods in stratified medicine. His other research interests include the application of causal inference methods in pharmacoepidemiology and routinely collected datasets (eHealth). He is a member of the MRC Health eResearch Centre, part of the Farr Institute, a co-investigator and theme lead on the MRC North West Hub for Trials Methodology Research, and a scientific collaborator on the AR UK Centre of Excellence in Epidemiology and the MRC Manchester Molecular Pathology Innovation Centre (MMPathIC).
As well as being the Deputy Director for MAHSC-CTU, Richard is the initiator and member of the steering group for the UK Causal Inference Meeting (UK-CIM), secretary of the Mental Health Research Network Methodology Research Group, and a member of the Psychosis Research Partnership project, funded by The Wellcome Trust and led from the Institute of Psychiatry, Psychology and Neuroscience.
For further details of Richard’s research and publications, see his research profile at the University of Manchester.
MAHSC-CTU Clinical Director
Juan is Consultant Medical Oncology at Christie NHS Foundation Trust, and Honorary Professor of Medical Oncology at University of Manchester.
Juan is based in the Department of Medical Oncology at The Christie NHS Foundation Trust within the gastrointestinal disease group and treats cancers of the pancreas, liver and biliary tract, neuroendocrine tumours and colorectal cancer. He is the lead clinician of The Christie’s Neuroendocrine Tumour Service, awarded European Centre of Excellence status in March 2011.
Juan is a member of the UK National Cancer Research Network (NCRN) upper gastrointestinal clinical studies group and a co-founding member of its cholangiocarcinoma working party. He also sits on the NCRN pancreatic cancer and hepatobiliary subgroups and chairs the Neuroendocrine subgroup. He has been awarded a number of grants for research leading to numerous publications and presentations, as well as national and international meetings, and he is a peer reviewer for a number of international medical journals. Juan is a member of ASCO (American Society of Clinical Oncology), ESMO (European Society of Medical Oncology), UKINETS (UK and Ireland Neuroendocrine Tumour Society) and ENETS (European Neuroendocrine Tumour Society).
For further details of Juan’s research and publications see his research profile at the University of Manchester.
MAHSC-CTU Associate Director
Philip is an experienced senior operations director having held a number of management positions within both the pharmaceutical industry and NHS. Over a period of nearly forty years, Philip has developed a detailed and comprehensive knowledge of regulatory affairs and clinical trials management within the biologics, pharmaceutical and medical device industry (US and Europe).
Philip has held the position of Associate Director for MAHSC-CTU for the past three years and prior to that has held roles as Business and Operations Manager at The Christie CTU (2009 to 2013), Regulatory Compliance Manager at both Novartis Vaccines and Diagnostics (2006 to 2008) and Chiron Vaccines (2003 to 2006) and Head of Regulatory Affairs at Powderject (2000 to 2003).
|David Ryder Senior Statistician
David Ryder: over 25 years’ experience as a medical statistician at The Christie NHS Foundation Trust collaborating with scientists and clinical investigators primarily in cancer; has been a co-applicant on a number of successful grant applications including two currently recruiting CRUK-funded phase III trials.
David ensures that biostatistics expertise is integrated into our strategy and available to the team and our collaborators.
We have two experienced operational managers working with our Team Leads to provide leadership and operational support to the trial teams.
|Ian Emerson Operations and Governance Manager||Sally Drake Interim Operations Manager|
MAHSC-CTU Deputy Director
MAHSC-CTU Clinical Director
MAHSC-CTU Associate Director