Inflammation & repair

Inflammation and repair

201.07I&R

Manchester is internationally recognised as a centre of expertise for research into inflammation and repair.

We aim to translate our interdisciplinary excellence in inflammation and regenerative medicine research and education into the highest quality multi-professional care for patients with inflammatory diseases.

Inflammatory disease is a major health burden on the population, and affects a wide range of systems and organs. Inflammatory disease can be debilitating for patients, and the way in which the body repairs itself following inflammation as well as the impact of treatment may cause further suffering – an area of inflammatory medicine that is still not fully understood. The subspecialties included in this domain include Acute Tissue Injury and Trauma; Dermatology; Gastroenterology and Hepatology; Musculoskeletal Disease including Rheumatology and Orthopaedics; Nephrology; Regenerative Medicine and Respiratory Medicine.

Through the MAHSC collaboration, we have harnessed the research power of The University of Manchester and work to ensure new scientific findings are translated into higher standards of healthcare through major NHS partner Trusts. The Institute of Inflammation and Repair at The University of Manchester includes global research leaders in many areas, linked by the common themes of inflammation and repair.

Much of our basic science research is conducted at the unique Manchester Collaborative Centre for Inflammation and Repair (MCCIR), a £15 million venture facilitated by MAHSC’s business development team and funded by AstraZeneca, GlaxoSmithKline and The University of Manchester. However, we also strive to introduce new collaborative centres – designed to bring experts in academia and healthcare to work on innovative new treatments and ways of delivering care – and take advantage of some of the world-class facilities already available in Manchester.

For instance, a number of exciting projects into arthritis, psoriasis, asthma and chronic cough are also being run at the NIHR Manchester Musculoskeletal Biomedical Research Unit and the three NIHR Clinical Research Facilities.

We are also leaders in stratified medicine, this is an approach that subdivides patients with a particular disease into sub-groups according to how they respond to therapies. The aim of the stratified medicine approach is to get the right treatment to the right person at the right time.  

Two major programmes of stratified medicine research have already attracted major funding and further applications for funding are under review.

The Arthritis Research UK-MRC MATURA programme led in Manchester by Professor Anne Barton will be using a range of techniques to identify biomarkers that can predict rheumatoid arthritis patients response to a range of biologic therapies. We know that delays in finding an effective treatment can have a detrimental effect on the long-term outcomes of the disease, so in the face of the availability of an increasing number of therapies it is vital that we develop strategies to ensure rapid selection of effective treatment.

Psoriasis Stratification to Optimise Relevant Therapy (PSORT) is a unique partnership between five UK universities: Manchester, King’s College London, Newcastle, Queen Mary and Liverpool, ten pharmaceutical and diagnostics companies and the Psoriasis Association and NHS partners representing patients. The four-year study will develop a targeted approach to treatment which could soon become reality for the one million NHS patients who suffer from the painful and potentially embarrassing skin condition, hair loss cure psoriasis.

Step Up and Boost Awards

The Inflammation and Repair Domain offers Step Up and Boost Awards to help clinicians, allied health professionals and clinical academics across the MAHSC partnership to apply for research grants in the fields of inflammation and repair..

To find out more and apply, please click here.

Case study

Networking events

We run regular networking events to explore areas where greater collaboration and understanding can further enhance clinical and translational research across Manchester. At the last one, we discussed opportunities to improve clinical care through research.

Please check the events section on this page for the next forum.

We welcome ideas for future events and activities.

Please contact Zoë Talks on 0161 901 0720 or email zoe.talks@cmft.nhs.uk for more information.


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