The Cardiovascular Domain’s mission is to apply discovery, translational science and excellence in clinical care, via single outward facing cohesive specialist cardiac services, to improve life expectancy for patients with cardiovascular disease in Greater Manchester.
This is also combined with training the next generation of healthcare staff and researchers to the highest standard. Through the strengths and catchment populations of MAHSC partners, we will take early discovery and innovation from basic underpinning research into practice, prove effectiveness, and disseminate best practice across the MAHSC footprint.
The population within our partners suffer disproportionately from heart and circulatory disease. Our services include two large tertiary cardiac units (Central Manchester University Hospitals NHS Foundation Trust and University Hospital of South Manchester) that together provide the highest quality specialist care to a population of around 3.5 million people with additional provision of nationally designated cardiopulmonary transplantation and ventricular assist services to 6.6 million people. Our partners also house major stroke and vascular surgery services.
In addition, the disease burden on the North West of England is particularly high for common diseases such as diabetes mellitus. We have successful research programmes that aim to improve the screening and treatment of this disease. We will:
(a) Address the high amputation rates due to the highly variable provision of diabetes care (National Audit Office-May 2012) by combining national retinal screening with our pioneering technique of corneal confocal microscopy to quantify early neuropathy across Greater Manchester (Year 2) and establish a model which can be replicated nationally (2020).
(b) Develop novel biomarkers and therapies for diabetic complications through the CADET facility. We will evaluate our candidate, Triethylenetetramine (TETA), which is approved by the FDA for Wilson’s disease, and has been identified as a new approach to treat copper-mediated oxidative stress and prevent or reverse the micro and macrovascular complications of diabetes.
The Cardiovascular Domain links basic science and transitional strength in The University of Manchester Institute for Cardiovascular Sciences and Faculty of Life Sciences, with cardiac and stroke care centres in the acute Trust partners, applied research in the Greater Manchester Collaboration for Leadership in Applied Health Research and Care (GM CLAHRC), and public health initiatives across the City Region. The integration of these activities will enable us to improve the identification and management of cardiovascular risk, conduct translational research and enhance care delivery in Manchester and beyond.
Meet the team
Professor Simon Ray
Joint Clinical Lead
Professor Daniel Keenan
Joint Clinical Lead
Professor Bernard Keavney