Stroke Research

Stroke Research

Pioneering basic research carried out by Professors Rothwell and Allan in  Manchester established the role of interleukin-1 in mediating neurological damage  following stroke in animal models, and showed that IL-1 receptor antagonism could reduce damage.

This finding is currently in the process of translation and  Phase II trials by Professor Tyrell and colleagues are currently in recruitment  through the Manchester Hyper-acute Stroke Research Centre based at Salford  Royal NHS Foundation Trust.

The Greater Manchester CLAHRC Stroke Theme (Tyrrell, Boaden) has developed a  post-stroke assessment tool now being adopted across the NHS.  The HTA-funded ACT-NoW study (led by Bowen) of speech therapy following  stroke showed that early intervention for communication disorders following  stroke, by speech therapists, is no better than an equivalent level of intervention  by volunteers; this finding has been adopted in the 2012 National Clinical   Guidelines for Stroke.


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