Endocrinology and Diabetes
Our research is based largely in The University of Manchester (AV Hill building) and Central Manchester University Hospitals NHS Foundation Trust.
Neuroendocrinology research addresses control of pituitary hormone gene expression in living cells and tissue (Davis) and hypothalamic-pituitary-adrenal axis function (Ray, A. White). Wellcome- and BBSRC-supported programmes on pituitary function involve long-standing collaborations with academic staff in the Faculty of Life Sciences (FLS: Loudon, M. White, Meng, Piggins, Luckman, UoA5), facilitated by adjacent laboratories in AV Hill and the Michael Smith buildings (Systems Microscopy Centre).
Inflammation and glucocorticoid sensitivity research (Ray) has developed a major programme on interaction of the endocrine system and inflammatory responsiveness with circadian timing mechanisms, again involving close collaboration with staff in FLS, including Loudon and Else (UoA5). Endocrine development research (Hanley, Piper-Hanley) is focussed on adrenal and pancreas, with distinctive expertise in human embryology. Interest in Sox9 biology has led to new insights into the nature of liver fibrosis, in collaboration with groups in Newcastle and Nottingham. Male reproductive health and ageing (Wu) has developed an internationally leading programme on male ageing, supported by major EU and MRC funding, and has provided critical new understanding of male hypogonadism using large European populations. Diabetes complications research (Boulton, Cooper, Malik, Rutter) has developed international strengths in understanding diabetic foot disease and has pioneered the use of corneal confocal microscopy to diagnose neuropathy (Malik) via NIH & JDRF funding and has embarked on a FP7 collaborative project applying genomic and transcriptomic analysis to probe the role of sodium channels in painful neuropathy. A metabolomics approach has provided new insights into the mechanisms and treatment of long-term diabetic complications (Cooper).
Well established cross-city links between NHS Endocrinology services based at Central Manchester, Christie and Salford Royal hospitals, provide tertiary care in specialist endocrine conditions, including pituitary tumours, adrenal and gonadal disease (collaborations with Brabant, Keevil and Trainer, Hon Chairs). Diabetes care across the teaching hospital sites is linked through the Diabetes and Obesity research network, a theme within the Greater Manchester CLRN, which allows immediate translation of research initiatives, for example in the management of neuropathic complications and the benefits of bariatric surgery into clinical care.