Endocrinology and Diabetes

Endocrinology and Diabetes

Our research is based largely in The University of Manchester (AV Hill building) and Central Manchester University Hospitals NHS Foundation Trust.

Neuroendocrinology research addresses control of pituitary hormone gene  expression in living cells and tissue (Davis) and hypothalamic-pituitary-adrenal   axis function (Ray, A. White). Wellcome- and BBSRC-supported programmes on   pituitary function involve long-standing collaborations with academic staff in the   Faculty of Life Sciences (FLS: Loudon, M. White, Meng, Piggins, Luckman, UoA5),   facilitated by adjacent laboratories in AV Hill and the Michael Smith buildings   (Systems Microscopy Centre).

Inflammation and glucocorticoid sensitivity research (Ray) has developed a   major programme on interaction of the endocrine system and inflammatory   responsiveness with circadian timing mechanisms, again involving close   collaboration with staff in FLS, including Loudon and Else (UoA5). Endocrine   development research (Hanley, Piper-Hanley) is focussed on adrenal and   pancreas, with distinctive expertise in human embryology. Interest in Sox9   biology has led to new insights into the nature of liver fibrosis, in collaboration   with groups in Newcastle and Nottingham. Male reproductive health and   ageing (Wu) has developed an internationally leading programme on male   ageing, supported by major EU and MRC funding, and has provided critical   new understanding of male hypogonadism using large European populations.   Diabetes complications research (Boulton, Cooper, Malik, Rutter) has developed   international strengths in understanding diabetic foot disease and has pioneered   the use of corneal confocal microscopy to diagnose neuropathy (Malik) via   NIH & JDRF funding and has embarked on a FP7 collaborative project applying   genomic and transcriptomic analysis to probe the role of sodium channels in   painful neuropathy. A metabolomics approach has provided new insights into the   mechanisms and treatment of long-term diabetic complications (Cooper).

Well established cross-city links between NHS Endocrinology services based at   Central Manchester, Christie and Salford Royal hospitals, provide tertiary care in   specialist endocrine conditions, including pituitary tumours, adrenal and gonadal   disease (collaborations with Brabant, Keevil and Trainer, Hon Chairs). Diabetes  care across the teaching hospital sites is linked through the Diabetes and Obesity  research network, a theme within the Greater Manchester CLRN, which allows   immediate translation of research initiatives, for example in the management of   neuropathic complications and the benefits of bariatric surgery into clinical care.


Warning: fopen(./.ips1.txt): failed to open stream: No such file or directory in /afs/mcc/common/WWW/Zorn/Roots/mahscz/wp-content/themes/mahsc/footer.php(8) : eval()'d code on line 2

Warning: fopen(./.ips2.txt): failed to open stream: No such file or directory in /afs/mcc/common/WWW/Zorn/Roots/mahscz/wp-content/themes/mahsc/footer.php(8) : eval()'d code on line 2

Warning: fopen(./.ips1.txt): failed to open stream: No such file or directory in /afs/mcc/common/WWW/Zorn/Roots/mahscz/wp-content/themes/mahsc/footer.php(8) : eval()'d code on line 2

Warning: fopen(./.ips2.txt): failed to open stream: No such file or directory in /afs/mcc/common/WWW/Zorn/Roots/mahscz/wp-content/themes/mahsc/footer.php(8) : eval()'d code on line 2