Coronary and Vascular Disease

Coronary and Vascular Disease

Researchers in the Institute of Cardiovascular Sciences (Heagerty, Greenstein) have shown that perivascular adipose tissue functions as a vasorelaxant, by a mechanism involving the local release of mediators.

Their work has demonstrated  that this vasorelaxant function is deficient in adipose tissue from obese and  diabetic people. This work, carried out on volunteer samples obtained in the  NIHR / Wellcome Trust Manchester Clinical Research Facility has the potential to  identify novel translational avenues for the treatment of hypertension.

Clinicians within CMFT and UHSM have successfully reorganised the provision  of Primary Percutaneous Coronary Intervention Services across the two units.  This achievement has enabled MAHSC to provide integrated care for acute  myocardial infarction to a population of 2.8 million people, arguably the largest  such catchment in Europe. This provides an opportunity unequalled in the UK to  conduct research into acute coronary syndromes in the next five years. Professor McCollum and colleagues in vascular surgery lead the largest  aneurysm screening program in the UK and are developing novel methods of risk  stratification in carotid disease.

Cardiovascular outcomes research is strong within MAHSC – Professor Ben  Bridgewater and colleagues at UHSM played a key role in the drive to publish  surgeon-specific survival rates following cardiothoracic surgery. Dr Mamas  Mamas and colleagues have conducted practice-altering research utilising national  audit databases to quantify the factors associated with bleeding risk following  percutaneous coronary intervention. In the next five years the designation of  Manchester as one of the UK’s e-Health Research Centres will add to our existing  outcomes research capacity and establish MAHSC as a leading centre in the  provision of data-drive improvements in patient care.

Dr Matthias Schmitt and colleagues at UHSM have developed novel methods for  the assessment of myocardial structure and mechanics using cardiac magnetic  resonance imaging and are applying these to a variety of clinical situations  including cardiac transplantation, hypertrophic cardiomyopathy and post  chemotherapy cardiomyopathy


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