Coronary and Vascular Disease
Researchers in the Institute of Cardiovascular Sciences (Heagerty, Greenstein) have shown that perivascular adipose tissue functions as a vasorelaxant, by a mechanism involving the local release of mediators.
Their work has demonstrated that this vasorelaxant function is deficient in adipose tissue from obese and diabetic people. This work, carried out on volunteer samples obtained in the NIHR / Wellcome Trust Manchester Clinical Research Facility has the potential to identify novel translational avenues for the treatment of hypertension.
Clinicians within CMFT and UHSM have successfully reorganised the provision of Primary Percutaneous Coronary Intervention Services across the two units. This achievement has enabled MAHSC to provide integrated care for acute myocardial infarction to a population of 2.8 million people, arguably the largest such catchment in Europe. This provides an opportunity unequalled in the UK to conduct research into acute coronary syndromes in the next five years. Professor McCollum and colleagues in vascular surgery lead the largest aneurysm screening program in the UK and are developing novel methods of risk stratification in carotid disease.
Cardiovascular outcomes research is strong within MAHSC – Professor Ben Bridgewater and colleagues at UHSM played a key role in the drive to publish surgeon-specific survival rates following cardiothoracic surgery. Dr Mamas Mamas and colleagues have conducted practice-altering research utilising national audit databases to quantify the factors associated with bleeding risk following percutaneous coronary intervention. In the next five years the designation of Manchester as one of the UK’s e-Health Research Centres will add to our existing outcomes research capacity and establish MAHSC as a leading centre in the provision of data-drive improvements in patient care.
Dr Matthias Schmitt and colleagues at UHSM have developed novel methods for the assessment of myocardial structure and mechanics using cardiac magnetic resonance imaging and are applying these to a variety of clinical situations including cardiac transplantation, hypertrophic cardiomyopathy and post chemotherapy cardiomyopathy